2-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine → 6-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

HRID 1252283Notes

Reaction equation

HRID 1252283 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:23](=[O:24])[N:22]([CH2:25][CH3:26])[CH2:21][CH2:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:25]([N:22]1[CH2:21][CH2:20][C:18]2[N:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:15]=[CH:16][C:17]=2[C:23]1=[O:24])[CH3:26]

Participants

5

Reactant 2

HCID 137841212-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 178418361HCID 178418361, compound

Product 1

HCID 137841226-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineYield 96.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In 20 ml of ethanol was dissolved 0.70 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. Thereto was added 10% Pd-C, and the resulting mixture was stirred at 60° C. for 4 hours in a hydrogen atmosphere. After having been allowed to cool, the mixture was filtered to remove the catalyst and the filtrate was concentrated to obtain 0.50 g of 6-ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a crystal with an yield of 96%. The crystal was purified by immersion using ethyl acetate.

Workup

  1. temperatureto cool
  2. filtrationthe mixture was filtered
  3. customto remove the catalyst
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-80d50aaf71c8454aa406bba0069876ea
Source dataset
uspto-grants-1988_05
Patent number
US04742165

Reaction notes

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