反应详情

In 20 ml of ethanol was dissolved 0.70 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. Thereto was added 10% Pd-C, and the resulting mixture was stirred at 60° C. for 4 hours in a hydrogen atmosphere. After having been allowed to cool, the mixture was filtered to remove the catalyst and the filtrate was concentrated to obtain 0.50 g of 6-ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a crystal with an yield of 96%. The crystal was purified by immersion using ethyl acetate.

1. temperatureto cool
2. filtrationthe mixture was filtered
3. customto remove the catalyst
4. concentrationthe filtrate was concentrated