Sodium Thiosulfate → HCID 141551044, compound

Participants

Reaction Steps

23.4 g (22.3 mmol) of benzhydryl 7-[(Z)-2-(benzhydryloxycarbonylmethoxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]-3-chloromethyl-3-cephem-4-carboxylate was dissolved in 500 ml of methylene chloride, and 4.8 g (22.3 mmol) of m-chloroperbenzoic acid was added over a period of 10 minutes under cooling with ice. The mixture was stirred for further 20 minutes. After an addition of 150 ml of a 10% sodium thiosulfate aqueous solution, the reaction solution was subjected to liquid separation. The organic layer was washed with a 5% sodium bicarbonate aqueous solution, then dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a powder of the above identified compound (the powder was used to the subsequent reaction without purification).

Provenance & Evidence