Sodium Iodide → HCID 141551542, compound

Participants

Reaction Steps

The compound obtained in (A) was dissolved in 380 ml of acetone, and 7.4 g (49 mmol) of sodium iodide was added thereto. The mixture was stirred at room temperature for 30 minutes. To the reaction solution, 300 ml of a 10% sodium thiosulfate aqueous solution and 1150 ml of ethyl acetate were added for liquid separation. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel flush column chromatography (ethyl acetate/n-hexane=1/1) to obtain 22.4 g (yield based on the previous step: 86.7%) of a powder of the above identified compound.

Provenance & Evidence