N,N-Dimethylaniline → HCID 178525023, compound

Participants

Reaction Steps

2.12 g (3 mmol) of (Z)-2-(1-benzhydryloxycarbonyl-1-cyclopentyloxyimino)-2-(2-tritylaminothiazol-4-yl) acetic acid and 1.24 g (3 mmol) of benzhydryl 7-amino-3-chloromethyl-3-cephem-4-carboxylate were dissolved in 50 ml of methylene chloride, and 1.2 ml (9.6 mmol) of N,N-dimethylaniline was added under cooling with ice. Then, 0.29 ml (3.15 mmol) of phosphorus oxychloride was dropwise added thereto, and the mixture was stirred at the same temperature for 4 hours. 30 ml of chloroform and 30 ml of water was added to the reaction solution. The organic layer was washed with water and with a saturated sodium chloride aqueous solution, then dried over anhydrous sodium sulfate and concentrated to obtain the residue of the above identified compound, which was used for the subsequent reaction without purification.

Provenance & Evidence