反应详情

温度

-10 °C

A solution of 32 g of 5-methyl-2-(3-pyridinyl)-1H-imidazole-4-carboxylic acid, ethyl ester (prepared as described above) in ethanol was heated to boiling. A 79 ml portion of hydrazine was added. This mixture was stirred at reflux for 14 hours and then cooled to -10° C. The mixture was taken to dryness in vacuo and then evaporated to dryness in vacuo twice from 125 ml portions of methyl cellosolve. The residue was shaken with 100 ml of ethanol and the solids collected, washed with 100 ml of ethanol and two 100 ml portions of ether and dried at 60° C. in vacuo, giving 18.7 g of 5-methyl-2-(3-pyridinyl)-1H-imidazole-4-carboxylic acid, hydrazide.

1. temperatureat reflux for 14 hours
2. customevaporated to dryness in vacuo twice from 125 ml portions of methyl cellosolve
3. stirringThe residue was shaken with 100 ml of ethanol
4. customthe solids collected
5. washwashed with 100 ml of ethanol and two 100 ml portions of ether
6. customdried at 60° C. in vacuo