HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinemethanamine → 5-methyl-2-(2-pyridinyl)-1H-imidazole-3-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | Ethyl 2,3-dioxobutanoate | HCID 12260829 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-methyl-2-(2-pyridinyl)-1H-imidazole-3-carboxylic acid, ethyl ester | HCID 86742156 | 106.5% |
Reaction Steps
A mixture of 23.8 g of 2,3-dioxobutyric acid, ethyl ester, (Z)-2-oxime, 18 g of 2-aminomethyl pyridine and 250 ml of acetonitrile was refluxed for 7 hours and then stored at -10° C. overnight. The solid was collected, giving 20.68 g of 5-methyl-2-(2-pyridinyl)-1H-imidazole-3-carboxylic acid, ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04743586 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-7492aeaa95e2494e88ee1e2c521bf10c |
| Source note | uspto-grants-1988_05 |