HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → Ethyl 5-methyl-2-(4-methylphenyl)-1H-imidazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-Methylbenzylamine | HCID 66035 | — |
| Reactant | Ethyl 2,3-dioxobutanoate | HCID 12260829 | — |
| Product | Ethyl 5-methyl-2-(4-methylphenyl)-1H-imidazole-4-carboxylate | HCID 43445104 | — |
Reaction Steps
A mixture of 10.7 g of 4-methylbenzylamine, 12.7 g of 2,3-dioxobutyric acid, ethyl ester, (Z)-2-oxime and 160 ml of acetonitrile was stirred and refluxed for 3.5 hours. The mixture was cooled, the solid collected and recrystallized from ethanol, giving 6.2 g of 5-methyl-2-(4-methylphenyl)-1H-imidazole-4-carboxylic acid, ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04743586 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-24b851c410a74f65b7243447edd514f9 |
| Source note | uspto-grants-1988_05 |