Cyclohexene → N-[3-carboxy-2-(2-methylpropyl)propenoyl]-O-methyl-L-tyrosine N-methylamide

Participants

Reaction Steps

E and Z N-[3-(benzyloxycarbonyl)-2-(2-methylpropyl)propenoyl]-O-methyl-L-tyrosine N-methylamide (3.0 g.) was heated under reflux for 2 hours in ethanol (60 mls.) and cyclohexene (30 mls.) in the presence of 10% palladium on charcoal (0.75 g.). The resultant reaction mixture was filtered through Celite and the solvent removed by evaporation in vacuo to yield a gum. This gum was crystallized from methanol/water to yield E and Z N-[3-carboxy-2-(2-methylpropyl)propenoyl]-O-methyl-L-tyrosine N-methylamide.

Provenance & Evidence