Ethanolamine → HCID 14209234, compound

HRID 1252397Notes

Reaction equation

HRID 1252397 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH2:13]([CH2:15][NH2:16])[OH:14]>O>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:16][CH2:15][CH2:13][OH:14])=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

4

Reactant 2

HCID 700EthanolamineHCID 6183063-Bromo-4-chloroquinoline

Product 1

HCID 14209234HCID 14209234, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 9.1 g of 3-bromo-4-chloro-quinoline and 2.0 g of ethanolamine was heated at 150° C. for 30 minutes. The reaction mixture was cooled, 60 ml of water was added and the precipitate was collected by filtration and recrystallized from isopropanol. The yield was 9.5 g, mp 163°-165° C.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe precipitate was collected by filtration
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-3b0008b4baf14a619161af1e78ef9f03
Source dataset
uspto-grants-1988_05
Patent number
US04743601

Reaction notes

Loading…