Water → HCID 14209239, compound

HRID 1252402Notes

Reaction equation

HRID 1252402 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:4][CH2:3][CH:2]([OH:13])[CH3:11])=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 962WaterHCID 6183063-Bromo-4-chloroquinoline

Product 1

HCID 14209239HCID 14209239, compound

Conditions

Temperature
150 °C

Procedure

A mixture of 3 g of 3-bromo-4-chloro-quinoline and 10 g of aminopropanol-2 was heated to 150° C. for 20 minutes. The mixture was cooled and poured into 120 ml of water and the product was extracted with 100 ml of ether. The ether layer was dried over sodium sulfate, the solvent removed by evaporation and the residue recrystallized from ether/hexane. The yield was 2.6 g, mp 82°-83° C.

Workup

  1. temperatureThe mixture was cooled
  2. extractionthe product was extracted with 100 ml of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent removed by evaporation
  5. customthe residue recrystallized from ether/hexane

Sources & evidence

ORD record
ord-ccca9300df774a6ba48d9a6574112126
Source dataset
uspto-grants-1988_05
Patent number
US04743601

Reaction notes

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