Bromine → 3-Bromo-N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine

HRID 1252405노트

반응식

HRID 1252405 반응식
[Br:1]Br.[OH:3][CH:4]([CH2:18][OH:19])[CH2:5][NH:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[C:9]([CH3:17])[CH:8]=1>C(O)(=O)C>[Br:1][C:8]1[C:9]([CH3:17])=[N:10][C:11]2[C:16]([C:7]=1[NH:6][CH2:5][CH:4]([OH:3])[CH2:18][OH:19])=[CH:15][CH:14]=[CH:13][CH:12]=2

참가 물질

4

반응물 2

HCID 24408BromineHCID 142092313-[(2-Methylquinolin-4-yl)amino]propane-1,2-diol

생성물 1

HCID 142092413-Bromo-N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Bromine (33.7 g) was added dropwise to a solution of 49 g of N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine in 600 ml of acetic acid. After two hours of stirring, the resultant oil was separated by decantation, dissolved in 500 ml of water and the mixture made alkaline (pH=10) with potassium carbonate. The resultant free base solid was filtered and recrystallized from ethanol. The yield was 33 g, mp 140°-141° C.

후처리

  1. customthe resultant oil was separated by decantation
  2. dissolutiondissolved in 500 ml of water
  3. filtrationThe resultant free base solid was filtered
  4. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-291965c37ed746048f0c012b81ea09cb
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743601

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