Hydrochloric Acid → HCID 20139964, compound

Participants

Reaction Steps

Ethyl 2-(5-n-butylthiophen-2-yl)-cyclopropanecarboxylate (12.6 g, 0.05 mol) was dissolved in methanol (70 ml) and a solution of potassium hydroxide (6.5 g, 0.12 mol) in water (70 ml) added dropwise at room temperature. The solution was refluxed for 3 hours, cooled to room temperature and carefully neutralised with 2M HCl. Saturated sodium chloride was added, the aqueous solution extracted with ethyl acetate (4×75 ml) and dried over anhydrous sodium sulphate. Removal of the solvent gave 2-(5-n-butylthiophen-2-yl)-cyclopropanecarboxylic acid (10.0 g, 89%).

Provenance & Evidence