Ethanol → HCID 20140046, compound

Participants

Reaction Steps

Isoquinolin-5-one (21.57 g, 0.147M) and hydroxylamine (15.55 g, 0.22M) together with approximately 300 ml of dry ethanol and 75 ml of pyridine was stirred at reflux temperature of the mixture for 6 hours. The solvent was then removed by evaporation and the residue was dissolved in a mixture of diethyl ether and water (600 ml, ca. 1:1). The organic phase was separated and extracted with water to remove residual pyridine, washed with saturated, aqueous solution of sodium chloride and dried over magnesium sulfate crystals. The inorganic matter was removed by filtration and the solvent by evaporation leaving 14.7 grams of the desired product (61.7% yield).

Provenance & Evidence