Phenylacetyl chloride → HCID 15169592, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4.2 g (13.2 mmol) of the product of Example I in 35 mL of dimethylformamide is added 3.1 g (19.3 mmol) of phenylacetylchloride in a dropwise fashion. The resulting mixture is stirred at 65° C. under nitrogen for 40 hours. The reaction mixture is cooled and filtered. The filtrate is diluted with 200 ml of ethyl ether and the resulting precipitate is subjected to flash chromatography on silica gel utilizing 5% methanol in methylene chloride as the eluent. The eluates are analyzed utilizing thin layer chromatography and appropriate fractions are combined and evaporated to produce the above referenced products (1) and (2).

Provenance & Evidence