1-(1-Oxo-3-phenylpropyl)-L-proline methyl ester → HCID 13632918, compound

HRID 1252499Notes

Reaction equation

HRID 1252499 reaction equation
C[O:2][C:3](=O)[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9](=[O:18])[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.COC(=O)[C@@H]1CCCN1C(=O)CC1C=CC=CC=1>>[C:12]1([CH2:11][CH2:10][C:9]([N:5]2[CH2:6][CH2:7][CH2:8][C@H:4]2[CH2:3][OH:2])=[O:18])[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 136329121-(1-Oxo-3-phenylpropyl)-L-proline methyl esterHCID 13632914HCID 13632914, compound

Product 1

HCID 13632918HCID 13632918, compound

Procedure

Instead of N-(3-phenylpropionyl)-proline methyl ester, (a) N-phenylacetyl-proline methyl ester (Compound No. 2), (b) N-(4-phenyl-n-butyryl)-proline methyl ester (Compound No. 6) and (c) N-(5-phenyl-n-valeryl)-proline methyl ester were used as starting compounds and treated by the procedures described above to obtain the following end compounds as oil: ##STR11##

Workup

  1. additiontreated by the procedures
  2. customto obtain the following end compounds as oil

Sources & evidence

ORD record
ord-e9a3cd71b4864977a1b8ed3e20e5e35d
Source dataset
uspto-grants-1988_05
Patent number
US04743616

Reaction notes

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