HCID 54382812, compound → HCID 13726886, compound

Participants

Reaction Steps

2.0 g (4.69 mmol) 4-(4-Ethoxyphenyl)-5,5-difluoro-1-(4-fluoro-3-phenoxyphenyl)-4-methyl-2-pentene was hydrogenated with hydrogen at atmospheric pressure with hydrogen in the presence of 0.2 g Raney nickel in 30 ml ethanol. After the calculated amount of hydrogen had been taken up, the catalyst was filtered off and the solvent removed under reduced pressure. After chromatography on silica gel, using hexane/toluene, 1.8 g of the desired product remained i.e. 89.6% of theory.

Provenance & Evidence