Sodium Iodide → HCID 13726886, compound

Participants

Reaction Steps

1.5 g (3.75 mmol) 1,1-difluoro-5-(4-fluoro-3-phenoxyphenyl)-2-(4-hydroxyphenyl)-2-methylpentane, 10 ml dimethylformamide, 700 mg (4.5 mmol) ethyl iodide and 725 mg (5.25 mmol) K2CO3 were heated at 80° C. for 8 hours with a catalytic amount of sodium iodide. It was then added to water, extracted with ethyl acetate, dried over Na2SO4 and evaporated. After chromatography on silica gel, using hexane/toluene, 1.4 g of the desired product remained i.e. 87.4% of theory. The physical data are identical for the product of Example 1. The starting material was obtained as follows

Provenance & Evidence