Pyridinium chloride → HCID 13726899, compound

Participants

Reaction Steps

27.22 g (65.68 mmol) 1,1-Difluoro-5-(4-fluoro-3-phenoxyphenyl)-2-(4-methoxyphenyl)-2-methylpentane was heated with 75.92 g (657 mmol) pyridine hydrochloride at 180° C. for 7 hours. It was then added to water, extracted with ethyl acetate, and the organic phase washed until it was neutral, dried over Na2SO4 and evaporated. After chromatography on silica gel, using toluene/ethyl acetate, 24.5 g of the desired product remained i.e. 93.1% of theory. Refractive index nD20 : 1.5571.

Provenance & Evidence