HCID 86742164, compound → HCID 20139846, compound

Participants

Reaction Steps

A stirred suspension of (±)-3,6-dioxo-2-(phenylmethyl)-4-piperidinecarboxylic acid, phenylmethyl ester, 1.59 g (0.0047 mole) and 0.2 g of 20% palladium on carbon in 200 ml of ethyl acetate was exposed to hydrogen gas for 15 minutes, the suspension was purged with nitrogen gas, filtered, and the solvent evaporated in vacuo and the residue chromatographed using 100 g of silica gel and eluting with 200 ml of dichloromethane-methanol (98:2) and 200 ml of dichloromethane-methanol (97:3) to give (±)-6-(phenylmethyl)-2,5-piperidinedione, 0.8 g; mp 140°-141°.

Provenance & Evidence