HCID 70403466, compound → HCID 57269490, compound

Participants

Reaction Steps

A solution of (2S,3R)-2-[[(2S)-2-benzyloxycarbonylamino-3-[N-[bis(4-methoxyphenyl)methyl]carbamoyl]propionyl]amino]-3-[[(1S)-1-carboxy-2-(3-indolyl)ethyl]amino]butyric acid (800 mg) in acetic acid (20 ml) was hydrogenated under medium pressure (3 atm.) for 8 hours at room temperature in the presence of 10% palladium on carbon (120 mg). After removal of the catalyst, the solution was evaporated in vacuo and the residue was solidified with water to give (2S,3R)-2-[[(2S)-2-amino-3-[N-[bis(4-methoxyphenyl)methyl]carbamoyl]propionyl]amino]-3-[[(1S)-1-carboxy-2-(3-indolyl)ethyl]amino]butyric acid (460 mg) as a yellow brown powder.

Provenance & Evidence