Hydrochloric Acid → HCID 178491197, compound

Participants

Reaction Steps

A solution of methyl (2S,3R)-2-[[(2S)-2-benzyloxycarbonylamino-3-[N-[bis(4-methoxyphenyl)methyl]carbamoyl]propionyl]amino]-3-[[2-(4-imidazolyl)ethyl]amino]butyrate (1.40 g) in a mixture of methanol (50 ml) and 1N aqueous sodium hydroxide (25 ml) was stirred for 30 minutes at room temperature and the mixture was adjusted to pH 7 with 1N hydrochloric acid. The precipitate was collected by filtration to give (2S,3R)-2-[[(2S)-2-benzyloxycarbonylamino-3-[N-[bis(4-methoxyphenyl)methyl]carbamoyl]propionyl]amino]-3-[[2-(4-imidazolyl)ethyl]amino]butyric acid (1.16 g) as a white powder.

Provenance & Evidence