反应详情

Compound (F) (5 g; 17.5 mmols) has been dissolved in warm toluene (25 ml). To this solution, an equimolar amount of potassium ter.butyrate has been added and the reaction mixture has been refluxed for 3 hours. Afterwards, almost all the solvent has been evaporated; water and ice have been added to the residue and the precipitate has been collected by filtration. The thus obtained crude (G) has been recrystallized from ethanol (3.7 g; yield, 88%); m.p. 130°-131° C.

1. temperaturethe reaction mixture has been refluxed for 3 hours
2. customAfterwards, almost all the solvent has been evaporated
3. additionwater and ice have been added to the residue
4. filtrationthe precipitate has been collected by filtration