Acetic Anhydride → HCID 11742046, compound

HRID 1252552Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]([O:9][C:10]([C:12]2[C:17]([O:18][C:19]([C:21]3[C:26]([OH:27])=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:20])=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[CH3:29][C:28]([O:27][C:26]1[C:21]([C:19]([O:18][C:17]2[C:12]([C:10]([O:9][C:8]3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][CH:7]=3)=[O:11])=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:20])=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:30]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 10248190HCID 10248190, compound

Product 1

HCID 11742046HCID 11742046, compound

Procedure

treating the guaiacol salsalate (II) with acetic anhydride to obtain guaiacol acetylsalsalate (III) in accordance with the reaction: ##STR4## In stage (a) the 2-hydroxybenzoylchloride is dissolved in an organic solvent, preferably 1,2-dichloroethane, the solution is cooled to a temperature of between -2° and +2° C., and N,N-dimethylaniline and guaiacol salsalate are added under energetic agitation.

Sources & evidence

ORD record: ord-3ee2c10578e4430e9058666d1f898201
Source dataset: uspto-grants-1988_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04743704

Reaction notes

Loading…