Sodium Hydroxide → 5-Hydroxy-2-[(2-oxo-1-imidazolidinyl)methyl]--4(1H)-pyridinone

HRID 1252609Notes

Reaction equation

HRID 1252609 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[OH:12][C:13]1[C:14](=[O:26])[CH:15]=[C:16]([CH2:19][N:20]2[CH2:24][CH2:23][NH:22][C:21]2=[O:25])[NH:17][CH:18]=1.[OH-].[Na+]>O>[OH:12][C:13]1[C:14](=[O:26])[CH:15]=[C:16]([CH2:19][N:20]2[CH2:24][CH2:23][NH:22][C:21]2=[O:25])[NH:17][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 141824775-Hydroxy-2-[(2-oxo-1-imidazolidinyl)methyl]-4(1H)-pyridinone, p-toluenesulfonate salt

Product 1

HCID 141824765-Hydroxy-2-[(2-oxo-1-imidazolidinyl)methyl]--4(1H)-pyridinoneYield 68.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Hydroxy-2-[(2-oxo-1-imidazolidinyl)methyl]-4(1H)-pyridinone, p-toluenesulfonate salt (4.0 g; 10.5 mmol) was dissolved in water (50 ml), and the pH was adjusted to 6.5 by the addition of 2N sodium hydroxide. The precipitate was filtered off by suction, washed with water, and dried in vacuo, yielding 1.5 g of the title compound, melting point 280° C., dec.

Workup

  1. filtrationThe precipitate was filtered off by suction
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-d758397ace4a4b8796caf8747bc74fee
Source dataset
uspto-grants-1988_05
Patent number
US04743685

Reaction notes

Loading…