反应详情

2-(Chloromethyl)-5-(phenylmethoxy)-1-(phenylmethyl)-4(1H)-pyridinone, hydrochloride (3.5 g, 9.3 mmol) was dissolved in a mixture of water/ethyl acetate and the layers separated. The organic phase was washed twice with water, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with petroleum ether, filtered off by suction and dried in vacuo, yielding 2.27 g of the title compound, melting point 115°-120° C., dec.

1. customthe layers separated
2. washThe organic phase was washed twice with water
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo
5. customThe residue was triturated with petroleum ether
6. filtrationfiltered off by suction
7. customdried in vacuo