HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4,5-bis(phenylmethoxy)-2-Pyridinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl 4,5-bis(benzyloxy)pyridine-2-carboxylate | HCID 14182499 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4,5-bis(phenylmethoxy)-2-Pyridinecarboxylic acid | HCID 14182507 | 91.6% |
Reaction Steps
To a solution of 11.8 g (28 mmol) of 4,5-bis(phenylmethoxy)-2-pyridinecarboxylic acid, phenylmethyl ester in 115 ml of tetrahydrofuran was added 16 ml of water and 35 ml of 1N potassium hydroxide. After stirring overnight at room temperature, 115 ml of water was added and the pH was adjusted to 2.5 with 1N hydrochloric acid. The acid was filtered off, washed with water and dried in vacuo, yielding 8.6 g of the title compound, melting point 203.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04743685 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-c797349715bb466c869c224aee970d03 |
| Source note | uspto-grants-1988_05 |