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温度

0 °C

A suspension of 1,4-dihydro-2-(hydroxymethyl)5-(phenylmethoxy)-4-pyridinone (3 g, 12.99 mmole) in chloroform (15 ml) was cooled to 0° C. under argon and treated with thionyl chloride (6.1 ml, 83.62 mmole). Within several minutes, a homogeneous solution was obtained. After stirring an additional 5 minutes, a cream colored solid precipitated. The cooling bath was removed and the mixture was heated at reflux for 45 minutes. The mixture was cooled to 0° C. and the white suspended material was filtered, washed with chloroform and hexane and dried in vacuo. The yield of the title compound was 3.65 g.

1. waitWithin several minutes
2. customa homogeneous solution was obtained
3. customprecipitated
4. customThe cooling bath was removed
5. temperaturethe mixture was heated
6. temperatureat reflux for 45 minutes
7. temperatureThe mixture was cooled to 0° C.
8. filtrationthe white suspended material was filtered
9. washwashed with chloroform and hexane
10. customdried in vacuo