反应详情

The compound prepared in Example 5 (3.4 g) was dissolved in diethyl ether (10 ml). The solution was added to a solution of triethylamine (2.2 g) and the compound prepared in Example 1 (6.1 g) in diethyl ether (50 ml) at 15°-20° C. The solution was stirred for 20 minutes, diethyl ether was added (20 ml), the solution was washed with water, and dried. The solvent was removed by evaporation. Column chromatography on silica using 50:50 (v/v) diethyl ether-dichloromethane as eluant yielded the title compound as a brown oil (5 g).

1. customat 15°-20° C
2. washthe solution was washed with water
3. customdried
4. customThe solvent was removed by evaporation