Ethanol → HCID 13827107, compound

Participants

Reaction Steps

A solution of ethyl-2-amino-6-ethyl-4-nitro-benzoate (400 mg) in ethyl acetate (10 ml) was added dropwise to a solution of trichloromethyl chloroformate in ethylacetate (10 ml). A precipitate was formed immediately which dissolved on prolonged sitrring for 21/2 hours. A solution of ethanol (5 ml) and triethylamine (5 ml) was added. A yellowish precipitate was formed. After 1 hour the solution was partitioned between ethylacetate and water. The ethylacetate layer was washed with brine solution, dried over magnesium sulfate and evaporated to a reddish oil. The material was further purified by column chromatography on silica gel (10% EtOAc:pet.ether) to give a solid material, m.p. 47°-48° C., IR: 1530, 1710, 1740, 1610 cm-1.

Provenance & Evidence