Methane → HCID 23670022, compound

Participants

Reaction Steps

Benzyl 6-(1-hydroxyethyl)-6-methyl-3-isopropylthio-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (25 mg) is dissolved in dioxane (2 ml) and the solution is treated with water (1 ml) containing sodium bicarbonate (6 mg) and 10% palladium on powdered charcoal (25 mg). The resulting mixture is hydrogenated at 40 psi for 1 hour. The catalyst is filtered off and washed with water (3 ml). The combined filtrate is extracted with ethylacetate (3×2 ml), concentrated in vacuo, and lyophilized to afford sodium 6-(1-hydroxyethyl)-6-methyl-3-isopropylthio-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.

Provenance & Evidence