4-Aminophenol → HCID 23684944, compound

Participants

Reaction Steps

Sodium aminophenoxide reactant was prepared by slowly adding sodium hydride (100%, 2.6 g, 0.11 mole) to a slurry of p-aminophenol (10.9 g, 0.1 mole) in about 100 mL tetrahydrofuran (THF). The reaction mixture was heated at 60°-67° C. for 3 hours, or until evolution of hydrogen was no longer visible. Sodium aminophenoxide salt, a purplish solid, formed during this time. The salt was either filtered and washed with THF, or used as prepared, as a slurry. The entire procedure was carried out under nitrogen.

Provenance & Evidence