2-(Trifluoromethyl)acrylic acid → 3-Acetylthio-2-trifluoromethylpropanoic acid

HRID 1252806Notes

Reaction equation

HRID 1252806 reaction equation
[C:1]([OH:6])(=[S:5])[CH:2](C)O.[F:7][C:8]([F:15])([F:14])[C:9](=[CH2:13])[C:10]([OH:12])=[O:11]>>[C:1]([S:5][CH2:13][CH:9]([C:8]([F:15])([F:14])[F:7])[C:10]([OH:12])=[O:11])(=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 5876942-(Trifluoromethyl)acrylic acidHCID 178473673HCID 178473673, compound

Product 1

HCID 128330143-Acetylthio-2-trifluoromethylpropanoic acid

Procedure

A mixture of thiolactic acid (50 g) and 2-(trifluoromethyl)acrylic acid [M. W. Buxton, et al., J. Chem Soc., 366 (1954)] (66 g) is heated on the steam bath for one hour and then stored at room temperature for eighteen hours. The reaction mixture is distilled in vacuo to give 3-acetylthio-2-trifluoromethylpropanoic acid.

Workup

  1. temperatureis heated on the steam bath for one hour
  2. waitstored at room temperature for eighteen hours
  3. distillationThe reaction mixture is distilled in vacuo

Sources & evidence

ORD record
ord-460d5ee2dd4142559165013c581f2b6b
Source dataset
uspto-grants-1988_05
Patent number
US04745124

Reaction notes

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