1-[3-Mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-proline → HCID 53645761, compound

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Reaction Steps

To a solution of the product from Example 62, Step (d) (3.0 g) in methanol (60 ml), 1N sodium hydroxide (60 ml) is added. After 4 hours, the solution is applied to a column of Dowex 50 ion exchange resin in the hydrogen cycle, and the desired material is eluted with water to yield 2.3 g of the named product, Rf =0.2 (silica gel-benzene:acetic acid, 75:25).

Provenance & Evidence