反应详情

2.1 g of the product from Example 62, Step (d) is dissolved in a mixture of water (40 ml) and concentrated ammonia (40 ml). After one hour the reaction mixture is concentrated in 1/3 volume, and applied to a column of Dowex 50 resin in the hydrogen cycle. The product is eluted with water. The aqueous is extracted with ethyl acetate and then concentrated to dryness to yield 1.4 g of the named product, Rf =0.50 (silica gel-chloroform:methanol:acetic acid:water).

1. concentrationAfter one hour the reaction mixture is concentrated in 1/3 volume
2. washThe product is eluted with water
3. extractionThe aqueous is extracted with ethyl acetate
4. concentrationconcentrated to dryness