HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → Dl-Phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| Reactant | 1-(3-Mercapto-1-oxopropyl)-L-proline | HCID 99978 | — |
| Reactant | Boc-D-phenylalanine | HCID 637610 | — |
| Product | Dl-Phenylalanine | HCID 994 | — |
| Product | L-Phenylalanine | HCID 6140 | — |
| Product | D-Phenylalanine | HCID 71567 | — |
Reaction Steps
The desired compounds are prepared by substituting 2-mercaptopropanoyl-L-proline and 3-mercaptopropanoyl-L-proline for 2-D-methyl-3-mercaptopropanoyl-L-proline in the procedures of each of Examples 196-198, and reacting the mercapto compound with either Boc-D-phenylalanine, Boc-L-phenylalanine, or a 50:50 mixture thereof, to form the desired D-Phe, L-Phe or D,L-Phe derivative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04745124 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-5ee857c7f89641e58270234d5895151e |
| Source note | uspto-grants-1988_05 |