HCID 20130587, compound → HCID 20137731, compound

HRID 1252939Notes

Reaction equation

HRID 1252939 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[C:16]3[CH2:19][CH2:20][CH2:21][C:15]=3[N:14]([CH3:22])[C:13]2=[O:23])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C(O)(C)(C)C>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[C:16]3[CH2:19][CH2:20][CH2:21][C:15]=3[N:14]([CH3:22])[C:13]2=[O:23])=[CH:7][C:3]=1[C:4]([O:6][C:3]([CH3:7])([CH3:4])[CH3:2])=[O:5]

Participants

3

Reactant 1

HCID 20130587HCID 20130587, compound

Product 1

HCID 20137731HCID 20137731, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

using 2-chloro-4-fluoro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoic acid via the corresponding acid chloride and tert.butanol there is obtained tert.butyl 2-chloro-4-fluoro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]-pyrimidin-3-yl)-benzoate, 1H-NMR (CDCl3, 400 MHz) 7.76 ppm (d, 1H), 7.31 ppm (d, 1H), 3.41 ppm (s, 3H), 2.94 ppm (m, 2H), 2.81 ppm (m, 2H), 2.17 ppm (m, 2H), 1.57 ppm (s, 9H).

Sources & evidence

ORD record
ord-ba3b1ad7dcdc42239870c1e96cce9e63
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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