Isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate → Isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methylpropenyl]ureido}-benzoate

HRID 1252963Notes

Reaction equation

HRID 1252963 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]=[C:16]=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[NH2:18]/[C:19](/[CH3:27])=[C:20](/[CH3:26])\[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]([CH3:27])=[C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH3:26])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

3

Reactant 2

HCID 13519895Isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoateHCID 53642952(Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester

Product 1

HCID 67910821Isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methylpropenyl]ureido}-benzoate

Procedure

using isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate and ethyl 3-amino-2-methylcrotonate there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methylpropenyl]ureido}-benzoate, m.p. 145°-147° C.,

Sources & evidence

ORD record
ord-88ecd012dcb84771a5e4241eab556f93
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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