HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 54399293, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-(Dimethoxyphosphoryl)acetic acid | HCID 189964 | — |
| Reactant | Methyl 4-aminopyridine-2-carboxylate | HCID 3759117 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54399293 | HCID 54399293 | — |
Reaction Steps
A mixture of 1.0 g of methyl 4-aminopicolinate, 1.0 g of α-(dimethylphosphono)-acetic acid and 1.0 g of dicyclohexylcarbodiimide in 10 ml of methylene chloride is stirred at room temperature for 6 hours. After filtration and removal of solvent the residue is chromatographed on silica gel with 5% methanol/methylene chloride as the eluent to afford methyl 4-(α-dimethylphosphonoacetamido)-picolinate as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04746653 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-a2a22c313bd44465a2801eae875476c0 |
| Source note | uspto-grants-1988_05 |