反应详情

温度

145 °C

A mixture of 50 g (0.35 mole) of 4(aminomethyl)-1-methyl-4-piperidinol and 15.8 g (0.35 mole) of formamide was stirred at 145° C. for 6 hr and allowed to stand overnight. The mass spectra indicated the starting amine was still present. The reaction mixture was reheated to 160° C. and stirred for 1 hr. The heat was removed and 150 ml of toluene was added. On cooling 61 g of crystals were formed, m.p. 116°-122° C. A 5 g sample was recrystallized from toluene to give 4.2 g of the title compound, m.p. 122°-124° C.

1. waitto stand overnight
2. customwas reheated to 160° C.
3. stirringstirred for 1 hr
4. customThe heat was removed
5. addition150 ml of toluene was added
6. temperatureOn cooling 61 g of crystals
7. customwere formed
8. customA 5 g sample was recrystallized from toluene