Boron tribromide → HCID 135583122, compound

HRID 1253008Notes

Reaction equation

HRID 1253008 reaction equation
C[O:2][C:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:12](=[O:14])[N:13]=[C:7]2[CH:6]=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:12](=[O:14])[N:13]=[C:7]2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 20137812HCID 20137812, compound

Product 1

HCID 135583122HCID 135583122, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 100 ml of methylene chloride was dissolved 25 g of the resulting 6-methoxybenzazepin-2-one, and 66 g of boron tribromide was added thereto dropwise at room temperature over 20 minutes. After stirring at room temperature for 1 hour, the reaction mixture was poured into ice-water, and the precipitated crystals were collected by filtration, washed with water, and dried to provide 18 g of 6-hydroxybenzazepin-2-one.

Workup

  1. additionwas added
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5a499bb38b5b4f35afff957d68a1d02d
Source dataset
uspto-grants-1988_05
Patent number
US04746602

Reaction notes

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