Acetyl chloride → 9-Chloro-7-[2-(2,4-di-t-amylphenoxy)butanoylamino]-6-hydroxy-1,5-benzodiazepin-2,4-dione

Participants

Reaction Steps

In a mixture of 160 ml of acetonitrile and 20 ml of dimethylacetamide was dispersed 40 g of the 5-amino-4-chloro-2-[2-(2,4-di-t-amylphenoxy)butanoylamino]phenol prepared in (1) above, and 6.6 ml of acetyl chloride was added dropwise thereto while refluxing. After stirring while refluxing for 1 hour, the reaction mixture was cooled. The precipitated crystals were collected by filtration and dried to provide 40.8 g of the desired compound.

Provenance & Evidence