HRID1253013

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID962

Water

H2O

2 次

HCID14798

Sodium Hydroxide

HNaO

结构：CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Nc1cc(Cl)c(NC(C)=O)c([N+](=O)[O-])c1O

HCID20137824

未命名化合物

PRODUCTS

生成物

结构：CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Nc1cc(Cl)c2c(c1O)=NC(=O)CC(=O)N=2

HCID135583124

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In 200 ml of methanol was dispersed 40 g of the 3-acetylamino-4-chloro-2-nitro-6-[2-(2,4-di-t-amylphenoxy)butanoylamino]phenol, and the dispersion was stirred while refluxing for 5 hours together with 9 g of sodium hydroxide and 40 ml of water. The reaction mixture was cooled to room temperature and then poured into 300 ml of water. Upon dropwise addition of 15 ml of acetic acid, red crystals were precipitated. The crystals were collected by filtration, recrystallized from acetonitrile, and dried to provide 21 g of the desired compound.

WORKUP

后处理

customwere precipitated
filtrationThe crystals were collected by filtration
customrecrystallized from acetonitrile
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-878e9f1b10144bd7971158454fcf9b16
来源数据集: uspto-grants-1988_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04746602
来源说明: uspto-grants-1988_05

反应 SMILES

[C:1]([NH:4][C:5]1[C:6]([N+:36]([O-])=O)=[C:7]([OH:35])[C:8]([NH:12][C:13](=[O:34])[CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([CH2:27][CH3:28])([CH3:26])[CH3:25])=[CH:20][C:19]=2[C:29]([CH2:32][CH3:33])([CH3:31])[CH3:30])[CH2:15][CH3:16])=[CH:9][C:10]=1[Cl:11])(=[O:3])[CH3:2].[OH-].[Na+].O.[C:42](O)(=[O:44])C>CO>[Cl:11][C:10]1[C:5]2=[N:4][C:1](=[O:3])[CH2:2][C:42](=[O:44])[N:36]=[C:6]2[C:7]([OH:35])=[C:8]([NH:12][C:13](=[O:34])[CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([CH2:27][CH3:28])([CH3:25])[CH3:26])=[CH:20][C:19]=2[C:29]([CH2:32][CH3:33])([CH3:30])[CH3:31])[CH2:15][CH3:16])[CH:9]=1