4-[Bis(4-fluorophenyl)methyl]piperidine → HCID 20138030, compound

Participants

Reaction Steps

4-[Bis(4-fluorophenyl)methyl]piperidine and 8-(2-chloroethyl)-6,7,8,9-tetrahydro-6-methyl-5H-pyrido[3,2-c]azepin-5-one in ethanol are reacted by heating to reflux for about 20 hr. The solution is concentrated on a rotary evaporator and the residue is partitioned between aqueous dilute base and chloroform. The chloroform layer is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed by high pressure liquid chromatography using ethyl acetate and triethylamine over silica. After concentrating the desired fraction, the residue is converted to the hydrochloride salt in isopropyl alcohol using hydrogen chloride.

Provenance & Evidence