Oxalic Acid → HCID 20138179, compound

HRID 1253024Notes

Reaction equation

HRID 1253024 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[O:17])[N:7]([CH3:16])[CH2:8][CH:9]([CH2:13][CH2:14]Cl)[CH2:10][C:11]=2[N:12]=1.[NH:18]1[CH2:21][CH2:20][CH2:19]1.[C:22]([OH:27])(=[O:26])[C:23]([OH:25])=[O:24]>>[C:22]([OH:27])(=[O:26])[C:23]([OH:25])=[O:24].[N:18]1([CH2:14][CH2:13][CH:9]2[CH2:8][N:7]([CH3:16])[C:6](=[O:17])[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[N:12][C:11]=3[CH2:10]2)[CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 971Oxalic AcidHCID 10422AzetidineHCID 20138072HCID 20138072, compound

Product 1

HCID 20138179HCID 20138179, compound

Procedure

Following the procedure of Example 21, 2-chloro-8-(2-chloroethyl)-6,7,8,9-tetrahydro-6-methyl-5H-pyrido[3,2-c]azepin-5-one and azetidine are reacted and the free base of the title is isolated and reacted with oxalic acid.

Workup

  1. customare reacted
  2. customthe free base of the title is isolated

Sources & evidence

ORD record
ord-286af4af2c294b6abdc86b55cd9b4c5a
Source dataset
uspto-grants-1988_05
Patent number
US04746657

Reaction notes

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