HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-benzyl-2-(chloromethyl)-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-benzyl-1H-imidazol-2-yl)methanol | HCID 311778 | — |
| Product | 1-benzyl-2-(chloromethyl)-1H-imidazole | HCID 736792 | 93.5% |
Reaction Steps
A mixture of 10 gm (45 mmole) of N-benzyl-2-hydroxymethylimidazole and 11 gm (92 mmole) of thionyl chloride was stirred at room temperature for 30 minutes before it was heated to reflux for 30 minutes. The excess thionyl chloride was removed under reduced pressure. The resultant residue (10 gm crude) was crystallized from ethanol/ether to obtain 8.7 gm of N-benzyl-2-chloromethylimidazole, m.p. 180°-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04746669 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-39fad1f746cd4c8a807fe30658bab454 |
| Source note | uspto-grants-1988_05 |