HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methylurea | HCID 11719 | — |
| Reactant | Ethyl 3,4-dimethoxybenzoylacetate | HCID 2758465 | — |
| Solvent | Tetralin | HCID 8404 | — |
| Product | 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione | HCID 13714258 | 40.3% |
Reaction Conditions
| Temperature | 170 °C |
|---|
Reaction Steps
To a solution of ethyl veratroylacetate (8.0 g) in tetralin (24 ml) was added N-methylurea (3.52 g) and the mixture was heated for an hour at 170° C. After being cooled to 95° C., ethyl acetate (33 ml) was added thereto. The precipitate was collected by filtration and washed with ethyl acetate to give 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (3.35 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04746664 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-ab485f7ebd5145889999a70d20d464d5 |
| Source note | uspto-grants-1988_05 |