HCID 13923414, compound → HCID 20138670, compound

Participants

Reaction Steps

200 mg of methyl 3-methoxy-4,5-methylenedioxybenzoylacetate (10) was suspended together with 20 mg of 5% Pd/C in 5 ml of methanol and subjected to hydrogenation at normal temperature and pressure. After the absorption of a predetermined amount of hydrogen was ascertained, the reaction mixture was filtered to remove the catalyst and then washed with methanol. On concentrating the filtrate, there was obtained 202 mg of methyl 3-hydroxy-3-(3-methoxy-4,5-methylenedioxyphenyl)propionate (11) as an oil with a quantitative yield.

Provenance & Evidence