反应详情

20 g (0.065 mole) of the product of Example 6 in 100 ml of methanol was hydrogenated for 2 days at room temperature and at 50 p.s.i. in the presence of 2 g of 10% Pd/C. The catalyst was filtered off and the solvent from the filtrate was removed under vacuum. The residue was taken up in ethyl ether, washed with H2O, 2X with sat. NaHCO3, 2X with H2O and dried over MgSO4. The ether was removed under vacuum and the residue was purified by HPLC (15% Et. Acet./Hexane) to yield 11.3 g (64%) of a clear liquid.

1. filtrationThe catalyst was filtered off
2. customthe solvent from the filtrate was removed under vacuum
3. washwashed with H2O, 2X with sat. NaHCO3, 2X with H2O
4. dry with materialdried over MgSO4
5. customThe ether was removed under vacuum
6. customthe residue was purified by HPLC (15% Et. Acet./Hexane)