反应详情

A solution of 2,2-dimethyl-4-methoxyindanone (13.7 g) in anhydrous diethyl ether (575 ml) is added dropwise to a stirred suspension of LAH (2.87 g) in anhydrous diethyl ether (575 ml) and the mixture is refluxed under nitrogen for two hours. The reaction mixture is quenched with H2O, 15% aq. NaOH and H2O, stirred overnight, filtered and the filtrate evaporated in vacuo affording the desired compound as a solid.

1. temperaturethe mixture is refluxed under nitrogen for two hours
2. customThe reaction mixture is quenched with H2O, 15% aq. NaOH and H2O
3. filtrationfiltered
4. customthe filtrate evaporated in vacuo