Sodium Bicarbonate → HCID 131715541, compound

Participants

Reaction Steps

A solution of p-nitrobenzyl (5R,6S)-2-methylsulfinyl-6-ethyl-pen-2-em-3-carboxylate (50 mg) in THF (9 ml) is diluted with EtOH (4.5 ml) and H2O (7.0 ml) containing NaHCO3 (10.6 mg). The resulting solution is added to a prereduced mixture of 10% Pd/C (100 mg) in EtOH (4.5 ml) and the resulting mixture is rapidly stirred under a H2 atmosphere for 2 hours. The mixture is filtered to remove the catalyst which is washed with H2O (2×25 ml). The combined filtrate is extracted with Et2O (2×50 ml) concentrated under vacuum to ca. 10 ml volume, and lyophilized to yield the title compound.

Provenance & Evidence